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While electroporation has been widely used as a physical method for gene transfection in vitro and in vivo, its application in gene therapy of cardiovascular cells remains challenging. Due to the high concentration of ion‐transport proteins in the sarcolemma, conventional electroporation of primary cardiomyocytes tends to cause ion‐channel activation and abnormal ion flux, resulting in low transfection...
A novel 3D cobalt sulfide (CoS) nanoparticle‐decorated nitrogen and sulfur co‐doped reduced graphene oxide aerogel (NSGA), referred to as CoS/NSGA, is prepared via three sequential processes, i.e., freeze‐drying, annealing, and sulfidization. The obtained CoS/NSGA exhibits excellent electrocatalytic performance in the alkaline solution.
Exocytosis of single‐walled carbon nanotubes (SWCNTs) determines therapeutic efficiency and toxicity of nanoproducts but its underlying mechanism remains elusive. In this study, it is found that the exocytosis mechanism of SWCNTs is mediated mainly through the activation of P2X7 receptor (P2X7R), an ATP‐gated membrane receptor highly expressed in macrophages. Inhibition of P2X7R signaling by either...
On page 5944, T. Zhang, D. Xing, and co‐workers utilize upconversion luminescent materials to construct a new theranostic nanoprobe. This probe detects and images specific tumor‐related mRNA and monitors target‐triggered therapeutic drug release according to the mRNA expression level under near infrared (NIR) irradiation.
Remote optical detection and imaging of specific tumor‐related biomarkers and simultaneous activation of therapy according to the expression level of the biomarkers in tumor site with theranostic probes should be an effective modality for treatment of cancers. Herein, an upconversion nanobeacon (UCNPs‐MB/Dox) is proposed as a new theranostic nanoprobe to ratiometrically detect and visualize the thymidine...
The exocytosis and underlying mechanism of single‐walled carbon nanotubes (SWCNTs) in macrophages is revealed by B. Wan, L.‐H. Guo, and co‐workers on page 5998. Exocytosis of SWCNTs is initiated by the activation of the P2X7 receptor, which accounts for the lysosomal secretion pathway as a potential mechanism for cells to repel SWCNTs. The cover image shows microtubules providing orbits for the exocytosis...
Protein‐based nanospheres, fabricated by protein and polypeptide co‐assembly, are developed as versatile drug delivery vehicles for photosensitizers. On page 5936, X. Yan and co‐workers describe how the responsiveness of nanospheres to changes in pH/redox/enzyme stimuli leads to efficient multi‐triggered tumor‐responsive photodynamic tumor ablation.
DNA replication is essential to maintain genome integrity in S phase of the cell division cycle. Accumulation of stalled replication forks is a major source of genetic instability, and likely constitutes a key driver of tumorigenesis. The mechanisms of regulation of replication fork progression have therefore been extensively investigated, in particular with DNA combing, an optical mapping technique...
A series of carbon dots/NiCo2O4 composites with various morphologies are prepared and tested for supercapacitors. These samples have good electrical conductivities and efficient ions transport paths, so they exhibit high specific capacitances, superior rate performances, and high cycling stabilities. The optimal composite for hybrid supercapacitor exhibits a high energy density up to 62.0 Wh kg−1...
The sustained or controlled release of nitric oxide (NO) can be the most promising approach for the suppression or prevention of restenosis and thrombosis caused by stent implantation. The aim of this study is to investigate the feasibility in the potential use of layer‐by‐layer (LBL) coating with a NO donor‐containing liposomes to control the release rate of NO from a metallic stent. Microscopic...
Much effort has been made to search for high energy and high power density electrode materials for lithium ion batteries. Here, a composite structure among Ge, C and Cu3Ge in Cu3Ge/Ge/C materials with a high rate performance of lithium batteries has been reported. Such Cu3Ge/Ge/C composite is synthesized through the in‐situ formation of Ge, C and Cu3Ge by one‐pot reaction. Density function theory...
Currently, the specific capacity and cycling performance of various MoS2/carbon‐based anode materials for Na‐ion storage are far from satisfactory due to the insufficient structural stability of the electrode, incomplete protection of MoS2 by carbon, difficult access of electrolyte to the electrode interior, as well as inactivity of the adopted carbon matrix. To address these issues, this work presents...
On page 5971, D. Gallego‐Perez, W. Lu, L. J. Lee, and co‐workers report an advanced Bio‐NEMS (nanoelectromechanical system) device for high‐throughput cell trapping and gene delivery on a silicon‐nanochannel array chip. With a thin‐film hydrodynamic approach, individual cells are precisely positioned on a nanochannel array where the molecules of well‐controlled dose are delivered into each cells....
When using the bottom‐up approach with anisotropic building‐blocks, an important goal is to find simple methods to elaborate nanocomposite materials with a truly macroscopic anisotropy. Here, micrometer size colloidal mesoporous particles with a highly anisotropic rod‐like shape (aspect ratio ≈ 10) have been fabricated from silica (SiO2) and iron oxide (Fe2O3). When dispersed in a solvent, these particles...
Rational design of nanostructures and efficient catalyst functionalization methods are critical to the realization of highly sensitive gas sensors. In order to solve these issues, two types of strategies are reported, i.e., (i) synthesis of peapod‐like hollow SnO2 nanostructures (hollow 0D‐1D SnO2) by using fluid dynamics of liquid Sn metal and (ii) metal–protein chelate driven uniform catalyst functionalization...
New techniques to directly grow metal oxide nanowire networks without the need for initial nanoparticle seed deposition or postsynthesis nanowire casting will bridge the gap between bottom‐up formation and top‐down processing for many electronic, photonic, energy storage, and conversion technologies. Whether etched top‐down, or grown from catalyst nanoparticles bottom‐up, nanowire growth relies on...
Tumor‐responsive nanocarriers are highly valuable and demanded for smart drug delivery particularly in the field of photodynamic therapy (PDT), where a quick release of photosensitizers in tumors is preferred. Herein, it is demonstrated that protein‐based nanospheres, prepared by the electrostatic assembly of proteins and polypeptides with intermolecular disulfide cross‐linking and surface polyethylene...
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